:root {
  --bg: #eef3f8;
  --surface: #ffffff;
  --surface-2: #f5f8fc;
  --line: #d9e3ef;
  --ink: #10233d;
  --ink-2: #4a5d78;
  --ink-3: #7486a0;
  --navy: #0b2545;
  --navy-2: #13406f;
  --accent: #1d6fd8;
  --accent-soft: #e3eefc;
  --diag-bg: #e2f4fb; --diag-line: #9ed3ea; --diag-ink: #0b5873;
  --trat-bg: #e7f6ee; --trat-line: #9fd8b8; --trat-ink: #17633b;
  --alerta-bg: #fff4e0; --alerta-line: #f4c27a; --alerta-ink: #8a4b00;
  --info-bg: #eef1fb; --info-line: #c3cbee; --info-ink: #33407a;
  --sim: #c2410c; --sim-bg: #fdebe3;
  --nao: #15803d; --nao-bg: #e5f5ea;
  --talvez: #b45309; --talvez-bg: #fdf3dc;
  --radius: 16px;
  --shadow: 0 1px 2px rgba(16, 35, 61, .06), 0 4px 16px rgba(16, 35, 61, .06);
  --font: "Segoe UI", system-ui, -apple-system, Roboto, "Helvetica Neue", Arial, sans-serif;
  --serif: Georgia, "Iowan Old Style", "Times New Roman", serif;
  color-scheme: light;
}
@media (prefers-color-scheme: dark) {
  :root:not([data-theme="light"]) {
    --bg: #0a1424; --surface: #111e33; --surface-2: #0e1a2d; --line: #22344f;
    --ink: #e6edf7; --ink-2: #a9b8cf; --ink-3: #7d8ea8;
    --accent: #5aa2ff; --accent-soft: #15294a;
    --diag-bg: #0f2c3a; --diag-line: #1f5a73; --diag-ink: #9fdcf3;
    --trat-bg: #0f2c1e; --trat-line: #23603f; --trat-ink: #9fe0bb;
    --alerta-bg: #33230a; --alerta-line: #7a5216; --alerta-ink: #f8cf8f;
    --info-bg: #1a2142; --info-line: #3a4682; --info-ink: #c3cbf5;
    --sim: #fb8b5c; --sim-bg: #3a1b10; --nao: #5fd08a; --nao-bg: #0f2e1b; --talvez: #f5c060; --talvez-bg: #33270b;
    --shadow: 0 1px 2px rgba(0,0,0,.3), 0 4px 16px rgba(0,0,0,.25);
    color-scheme: dark;
  }
}
:root[data-theme="dark"] {
  --bg: #0a1424; --surface: #111e33; --surface-2: #0e1a2d; --line: #22344f;
  --ink: #e6edf7; --ink-2: #a9b8cf; --ink-3: #7d8ea8;
  --accent: #5aa2ff; --accent-soft: #15294a;
  --diag-bg: #0f2c3a; --diag-line: #1f5a73; --diag-ink: #9fdcf3;
  --trat-bg: #0f2c1e; --trat-line: #23603f; --trat-ink: #9fe0bb;
  --alerta-bg: #33230a; --alerta-line: #7a5216; --alerta-ink: #f8cf8f;
  --info-bg: #1a2142; --info-line: #3a4682; --info-ink: #c3cbf5;
  --sim: #fb8b5c; --sim-bg: #3a1b10; --nao: #5fd08a; --nao-bg: #0f2e1b; --talvez: #f5c060; --talvez-bg: #33270b;
  color-scheme: dark;
}

* { box-sizing: border-box; }
html { -webkit-text-size-adjust: 100%; scroll-padding-top: 150px; }
body { margin: 0; background: var(--bg); color: var(--ink); font: 16px/1.55 var(--font); }
a { color: var(--accent); }
img { max-width: 100%; }
button { font: inherit; cursor: pointer; }
:focus-visible { outline: 3px solid var(--accent); outline-offset: 2px; border-radius: 6px; }
small { font-size: .85em; }
sup, sub { line-height: 0; }

/* ---------- Topo ---------- */
.topo {
  position: sticky; top: 0; z-index: 20;
  background: radial-gradient(120% 140% at 0% 0%, #1b4f86 0%, var(--navy) 55%, #071a33 100%);
  color: #fff; padding: 12px 16px 0; padding-top: max(12px, env(safe-area-inset-top));
  box-shadow: 0 4px 20px rgba(4, 18, 38, .35);
}
.topo-inner { max-width: 1240px; margin: 0 auto; display: flex; align-items: center; gap: 12px; justify-content: space-between; }
.marca { display: flex; align-items: center; gap: 10px; color: #fff; text-decoration: none; min-width: 0; }
.marca img { width: 40px; height: 40px; border-radius: 12px; flex: none; background: #fff; }
.marca span { display: flex; flex-direction: column; min-width: 0; }
.marca small { font-size: 10.5px; letter-spacing: .14em; text-transform: uppercase; color: #9cc3ef; font-weight: 600; }
.marca strong { font-family: var(--serif); font-size: 19px; font-weight: 700; line-height: 1.2; white-space: nowrap; overflow: hidden; text-overflow: ellipsis; }
.topo-acoes { display: flex; gap: 8px; align-items: center; flex: none; }
.btn-topo {
  display: inline-flex; align-items: center; gap: 8px; color: #fff; background: rgba(255,255,255,.1);
  border: 1px solid rgba(255,255,255,.22); border-radius: 999px; padding: 8px 14px; font-size: 14px; font-weight: 600;
}
.btn-topo:hover { background: rgba(255,255,255,.18); }
.btn-busca kbd { font: 600 11px var(--font); border: 1px solid rgba(255,255,255,.35); border-radius: 5px; padding: 0 5px; opacity: .75; }
.pill-status { font-size: 12px; font-weight: 700; padding: 4px 10px; border-radius: 999px; background: #f59e0b; color: #1f1300; }
.atalhos { max-width: 1240px; margin: 10px auto 0; display: flex; gap: 8px; align-items: center; overflow-x: auto; padding: 8px 0 12px; border-top: 1px solid rgba(255,255,255,.1); scrollbar-width: none; }
.atalhos::-webkit-scrollbar { display: none; }
.atalhos:empty { display: none; }
.atalhos .rotulo { font-size: 10.5px; letter-spacing: .14em; text-transform: uppercase; color: #9cc3ef; font-weight: 700; flex: none; margin-right: 4px; }
.chip-topo { flex: none; color: #fff; text-decoration: none; font-size: 13px; font-weight: 600; padding: 5px 12px; border-radius: 999px; background: rgba(255,255,255,.1); border: 1px solid rgba(255,255,255,.18); }
.chip-topo::before { content: "•"; margin-right: 6px; color: #7fb6f5; }
.chip-topo:hover { background: rgba(255,255,255,.2); }

/* ---------- Layout ---------- */
main { max-width: 1240px; margin: 0 auto; padding: 20px 16px 40px; outline: none; }
.grade { display: grid; grid-template-columns: 270px minmax(0, 1fr); gap: 20px; align-items: start; }
.card { background: var(--surface); border: 1px solid var(--line); border-radius: var(--radius); box-shadow: var(--shadow); }
.eyebrow { font-size: 11px; letter-spacing: .16em; text-transform: uppercase; color: var(--accent); font-weight: 700; margin: 0 0 4px; }
h1, h2, h3 { line-height: 1.25; margin: 0; }
h1 { font-family: var(--serif); font-size: clamp(26px, 4vw, 38px); }
h2 { font-family: var(--serif); font-size: 22px; }
h3 { font-size: 17px; }
.muted { color: var(--ink-2); }

/* Índice lateral */
.indice { position: sticky; top: 150px; padding: 14px; max-height: calc(100vh - 170px); overflow: auto; }
.indice-cab { display: flex; gap: 10px; align-items: center; padding: 4px 4px 12px; border-bottom: 1px solid var(--line); margin-bottom: 10px; }
.indice-cab .ico { width: 34px; height: 34px; border-radius: 50%; display: grid; place-items: center; background: var(--accent-soft); color: var(--accent); font-weight: 800; font-size: 13px; flex: none; }
.indice-cab strong { display: block; font-size: 15px; }
.grupo-btn { width: 100%; display: flex; align-items: center; gap: 10px; text-align: left; background: none; border: 1px solid transparent; border-radius: 12px; padding: 9px 8px; color: var(--ink); text-decoration: none; }
.grupo-btn:hover, .grupo-btn.ativo { background: var(--accent-soft); border-color: color-mix(in srgb, var(--accent) 30%, transparent); }
.sigla { width: 34px; height: 34px; border-radius: 50%; display: grid; place-items: center; border: 1px solid var(--line); background: var(--surface-2); font-size: 11.5px; font-weight: 800; letter-spacing: .06em; color: var(--ink-2); flex: none; }
.grupo-btn small { display: block; font-size: 10.5px; letter-spacing: .12em; text-transform: uppercase; color: var(--ink-3); font-weight: 700; }
.grupo-btn span { font-weight: 600; font-size: 14.5px; line-height: 1.25; }
.indice-topicos { list-style: none; margin: 2px 0 8px 52px; padding: 0; }
.indice-topicos a { display: block; font-size: 13.5px; color: var(--ink-2); text-decoration: none; padding: 4px 6px; border-radius: 8px; }
.indice-topicos a:hover, .indice-topicos a.ativo { color: var(--accent); background: var(--accent-soft); }

/* Hero */
.hero { padding: 26px; display: grid; grid-template-columns: minmax(0, 1fr) 260px; gap: 24px; }
.hero p { color: var(--ink-2); margin: 12px 0 0; }
.hero .como-usar { background: var(--surface-2); border: 1px solid var(--line); border-radius: 14px; padding: 16px; }
.como-usar ol { list-style: none; padding: 0; margin: 10px 0 0; counter-reset: c; }
.como-usar li { counter-increment: c; display: flex; gap: 10px; font-size: 14px; color: var(--ink-2); margin-bottom: 10px; }
.como-usar li::before { content: counter(c); flex: none; width: 24px; height: 24px; border-radius: 50%; display: grid; place-items: center; background: var(--accent-soft); color: var(--accent); font-weight: 700; font-size: 12px; }
.acoes-hero { display: flex; flex-wrap: wrap; gap: 8px; margin-top: 16px; }
.btn { display: inline-flex; align-items: center; gap: 6px; border-radius: 999px; padding: 9px 16px; font-weight: 600; font-size: 14px; text-decoration: none; border: 1px solid var(--line); background: var(--surface); color: var(--ink); }
.btn.primario { background: var(--accent); border-color: var(--accent); color: #fff; }

/* Seções de grupo */
.secao-grupo { margin-top: 26px; }
.secao-grupo-cab { display: flex; justify-content: space-between; align-items: baseline; gap: 10px; margin-bottom: 12px; }
.contador { font-size: 12px; font-weight: 600; color: var(--ink-2); border: 1px solid var(--line); border-radius: 999px; padding: 3px 10px; background: var(--surface); white-space: nowrap; }
.lista-topicos { display: grid; grid-template-columns: repeat(auto-fill, minmax(280px, 1fr)); gap: 12px; }
.topico-card { display: flex; flex-direction: column; gap: 6px; padding: 16px; text-decoration: none; color: var(--ink); transition: transform .12s, border-color .12s; }
.topico-card:hover { transform: translateY(-2px); border-color: var(--accent); }
.topico-card .linha { display: flex; gap: 10px; align-items: center; }
.num { flex: none; min-width: 34px; height: 34px; padding: 0 6px; border-radius: 10px; display: grid; place-items: center; background: var(--surface-2); border: 1px solid var(--line); font-weight: 700; font-size: 13px; color: var(--ink-2); }
.topico-card strong { font-size: 16px; line-height: 1.3; }
.topico-card p { margin: 0; font-size: 14px; color: var(--ink-2); }
.topico-card .ver { margin-top: auto; padding-top: 8px; border-top: 1px solid var(--line); text-align: right; font-size: 13.5px; font-weight: 700; color: var(--accent); }

/* Biblioteca */
.biblioteca { display: grid; grid-template-columns: repeat(auto-fill, minmax(300px, 1fr)); gap: 16px; margin-top: 18px; }
.guia-card { padding: 20px; text-decoration: none; color: var(--ink); display: flex; flex-direction: column; gap: 10px; border-top: 5px solid var(--cor, var(--accent)); }
.guia-card:hover { border-color: var(--accent); }
.guia-card .sigla-g { width: 46px; height: 46px; border-radius: 14px; display: grid; place-items: center; font-weight: 800; color: #fff; background: var(--cor, var(--accent)); }
.guia-card.em-breve { opacity: .7; border-style: dashed; border-top-style: solid; pointer-events: none; box-shadow: none; }

/* ---------- Página de tópico ---------- */
.topico-cab { position: sticky; top: 140px; z-index: 5; padding: 14px 18px; margin-bottom: 16px; }
.topico-cab .titulo-linha { display: flex; flex-wrap: wrap; align-items: center; gap: 8px 12px; }
.topico-cab h1 { font-size: clamp(22px, 3vw, 30px); }
.badge { font-size: 11px; letter-spacing: .12em; text-transform: uppercase; font-weight: 700; padding: 4px 10px; border-radius: 999px; background: var(--accent-soft); color: var(--accent); white-space: nowrap; }
.navsec { display: flex; gap: 6px; overflow-x: auto; margin-top: 10px; scrollbar-width: thin; padding-bottom: 2px; }
.navsec a { flex: none; font-size: 13px; font-weight: 600; text-decoration: none; color: var(--ink-2); border: 1px solid var(--line); border-radius: 999px; padding: 5px 12px; background: var(--surface-2); }
.navsec a:hover { color: var(--accent); border-color: var(--accent); }
.fonte-pag { font-size: 13px; color: var(--ink-3); margin-top: 6px; }
.bloco { margin-bottom: 16px; padding: 18px 20px; }
.bloco > h2 { font-size: 20px; margin-bottom: 10px; display: flex; align-items: center; gap: 10px; }
.bloco p { margin: 0 0 10px; }
.bloco p:last-child { margin-bottom: 0; }
.bloco ul, .bloco ol { margin: 6px 0; padding-left: 22px; }
.bloco li { margin-bottom: 6px; }
.bloco li::marker { color: var(--accent); }
.callout { border-radius: var(--radius); padding: 16px 20px; margin-bottom: 16px; border: 1px solid; }
.callout h2 { font-family: var(--font); font-size: 15px; letter-spacing: .08em; text-transform: uppercase; margin-bottom: 8px; display: flex; gap: 8px; align-items: center; }
.callout p { margin: 0 0 8px; } .callout p:last-child { margin: 0; }
.callout ul { margin: 4px 0; padding-left: 20px; }
.callout li { margin-bottom: 4px; }
.callout.diag { background: var(--diag-bg); border-color: var(--diag-line); } .callout.diag h2 { color: var(--diag-ink); }
.callout.trat { background: var(--trat-bg); border-color: var(--trat-line); } .callout.trat h2 { color: var(--trat-ink); }
.callout.alerta { background: var(--alerta-bg); border-color: var(--alerta-line); } .callout.alerta h2 { color: var(--alerta-ink); }
.callout.info { background: var(--info-bg); border-color: var(--info-line); } .callout.info h2 { color: var(--info-ink); }

/* Esquemas terapêuticos */
.esquemas { margin-bottom: 16px; overflow: hidden; }
.esquemas > .esq-cab { padding: 18px 20px 6px; }
.esq-cab h2 { font-size: 20px; }
.esq-intro { padding: 0 20px; color: var(--ink-2); font-size: 15px; }
.esq-intro p { margin: 8px 0; }
.esq-grupo-cab { margin-top: 12px; padding: 10px 20px; background: linear-gradient(90deg, var(--navy-2), var(--accent)); color: #fff; }
.esq-grupo-cab small { display: block; font-size: 10.5px; letter-spacing: .14em; text-transform: uppercase; opacity: .8; font-weight: 700; }
.esq-grupo-cab strong { font-size: 15.5px; }
.farmaco { padding: 14px 20px; border-top: 1px solid var(--line); }
.farmaco:first-of-type { border-top: 0; }
.farmaco-nome { display: flex; justify-content: space-between; align-items: center; gap: 10px; margin-bottom: 10px; }
.farmaco-nome h3 { font-size: 16.5px; }
.vias { display: flex; gap: 4px; flex-wrap: wrap; justify-content: flex-end; }
.via { font-size: 10.5px; font-weight: 800; letter-spacing: .08em; text-transform: uppercase; border: 1px solid var(--line); color: var(--ink-2); border-radius: 999px; padding: 3px 9px; white-space: nowrap; background: var(--surface-2); }
.doses { display: grid; grid-template-columns: repeat(auto-fit, minmax(220px, 1fr)); gap: 10px; }
.dose { border: 1px solid var(--line); background: var(--surface-2); border-radius: 12px; padding: 10px 12px; }
.dose small { display: block; font-size: 10.5px; letter-spacing: .14em; text-transform: uppercase; color: var(--ink-3); font-weight: 700; margin-bottom: 2px; }
.dose div { font-weight: 600; font-size: 15px; }
.dose.na div { color: var(--ink-3); font-weight: 500; }
.esq-nota { padding: 12px 20px 16px; font-size: 13.5px; color: var(--ink-2); border-top: 1px solid var(--line); background: var(--surface-2); }

/* Tabelas */
.tabela-wrap { overflow-x: auto; border: 1px solid var(--line); border-radius: 12px; }
table { border-collapse: collapse; width: 100%; font-size: 14.5px; }
th { text-align: left; background: linear-gradient(90deg, var(--navy-2), var(--accent)); color: #fff; font-size: 13px; letter-spacing: .03em; padding: 10px 12px; vertical-align: bottom; }
td { padding: 10px 12px; border-top: 1px solid var(--line); vertical-align: top; }
td ul { margin: 0; padding-left: 18px; }
tr.grupo td { background: var(--accent-soft); color: var(--accent); font-weight: 700; font-size: 13.5px; }
tbody tr:nth-child(even):not(.grupo) td { background: var(--surface-2); }
.filtro-tabela { width: 100%; margin-bottom: 10px; padding: 10px 14px; border-radius: 12px; border: 1px solid var(--line); background: var(--surface-2); color: var(--ink); font: inherit; }
.nota { font-size: 13.5px; color: var(--ink-2); margin-top: 10px; }
tr.oculto { display: none; }

/* Fluxos e decisões */
.fluxo { display: flex; flex-direction: column; gap: 0; }
.passo { border: 1px solid var(--line); border-radius: 14px; padding: 14px 16px; background: var(--surface-2); }
.passo h3 { font-size: 15.5px; margin-bottom: 6px; }
.passo ul { margin: 4px 0 0; }
.ramos { display: grid; grid-template-columns: 1fr 1fr; gap: 10px; margin-top: 10px; }
.ramos.unico { grid-template-columns: 1fr; }
.ramo { border-radius: 12px; padding: 10px 12px; font-size: 14.5px; border: 1px solid; }
.ramo > b:first-child { display: block; font-size: 11.5px; letter-spacing: .14em; text-transform: uppercase; margin-bottom: 4px; }
.ramo ul { margin: 2px 0 0; padding-left: 18px; }
.ramo.atb, .ramo.alerta { background: var(--sim-bg); border-color: color-mix(in srgb, var(--sim) 40%, transparent); }
.ramo.atb > b:first-child, .ramo.alerta > b:first-child { color: var(--sim); }
.ramo.nao-atb { background: var(--nao-bg); border-color: color-mix(in srgb, var(--nao) 40%, transparent); }
.ramo.nao-atb > b:first-child { color: var(--nao); }
.ramo.talvez { background: var(--talvez-bg); border-color: color-mix(in srgb, var(--talvez) 40%, transparent); }
.ramo.talvez > b:first-child { color: var(--talvez); }
.seta { text-align: center; color: var(--ink-3); font-size: 13px; font-weight: 700; padding: 6px 0; letter-spacing: .1em; }
.seta::before { content: "↓"; display: block; font-size: 18px; line-height: 1; }

/* Ferramentas interativas */
.ferramenta { border: 1px solid var(--line); border-radius: 14px; padding: 14px; background: var(--surface-2); }
.checks { display: grid; gap: 6px; }
.check { display: flex; gap: 10px; align-items: flex-start; padding: 8px 10px; border-radius: 10px; border: 1px solid var(--line); background: var(--surface); cursor: pointer; font-size: 14.5px; }
.check input { margin-top: 3px; width: 18px; height: 18px; accent-color: var(--accent); flex: none; }
.check .pts { margin-left: auto; font-weight: 700; color: var(--ink-2); font-size: 13px; white-space: nowrap; }
.check:has(input:checked) { border-color: var(--accent); background: var(--accent-soft); }
.radios { display: flex; flex-wrap: wrap; gap: 6px; margin: 8px 0; }
.radios label { display: inline-flex; gap: 6px; align-items: center; padding: 6px 12px; border: 1px solid var(--line); border-radius: 999px; background: var(--surface); font-size: 14px; cursor: pointer; }
.radios label:has(input:checked) { border-color: var(--accent); background: var(--accent-soft); color: var(--accent); font-weight: 600; }
.resultado { margin-top: 12px; border-radius: 12px; padding: 12px 14px; font-size: 15px; border: 1px solid var(--line); background: var(--surface); }
.resultado.baixo { background: var(--nao-bg); border-color: color-mix(in srgb, var(--nao) 40%, transparent); }
.resultado.medio { background: var(--talvez-bg); border-color: color-mix(in srgb, var(--talvez) 40%, transparent); }
.resultado.alto { background: var(--sim-bg); border-color: color-mix(in srgb, var(--sim) 40%, transparent); }
.resultado .grande { font-size: 26px; font-weight: 800; font-family: var(--serif); }
.campos { display: grid; grid-template-columns: repeat(auto-fit, minmax(150px, 1fr)); gap: 10px; }
.campo label { display: block; font-size: 12px; font-weight: 700; letter-spacing: .08em; text-transform: uppercase; color: var(--ink-3); margin-bottom: 4px; }
.campo input, .campo select { width: 100%; padding: 10px 12px; border-radius: 10px; border: 1px solid var(--line); background: var(--surface); color: var(--ink); font: inherit; }
.colunas-2 { display: grid; grid-template-columns: 1fr 1fr; gap: 12px; }
.ou { align-self: center; justify-self: center; font-weight: 800; color: var(--accent); }

/* Busca */
.busca { position: fixed; inset: 0; z-index: 50; background: rgba(5, 15, 30, .55); backdrop-filter: blur(3px); display: flex; justify-content: center; align-items: flex-start; padding: 8vh 16px 16px; }
.busca[hidden] { display: none; }
.busca-caixa { width: min(720px, 100%); max-height: 80vh; display: flex; flex-direction: column; background: var(--surface); border-radius: 18px; box-shadow: 0 20px 60px rgba(0,0,0,.35); overflow: hidden; border: 1px solid var(--line); }
.busca-campo { display: flex; gap: 10px; align-items: center; padding: 12px 16px; border-bottom: 1px solid var(--line); color: var(--ink-3); }
.busca-campo input { flex: 1; border: 0; outline: none; background: none; color: var(--ink); font-size: 17px; padding: 6px 0; min-width: 0; }
.busca-fechar { border: 1px solid var(--line); background: var(--surface-2); color: var(--ink-2); border-radius: 8px; padding: 3px 8px; font-size: 12px; }
.busca-resultados { overflow: auto; padding: 8px; }
.res { display: block; padding: 10px 12px; border-radius: 12px; text-decoration: none; color: var(--ink); }
.res:hover, .res.sel { background: var(--accent-soft); }
.res strong { display: block; font-size: 15px; }
.res .onde { font-size: 11.5px; letter-spacing: .1em; text-transform: uppercase; color: var(--accent); font-weight: 700; }
.res .trecho { font-size: 13.5px; color: var(--ink-2); display: block; margin-top: 2px; }
.res mark { background: color-mix(in srgb, var(--accent) 25%, transparent); color: inherit; border-radius: 3px; padding: 0 1px; }
.busca-vazio { padding: 24px; text-align: center; color: var(--ink-2); }
mark.destaque { background: #ffe58a; color: #1a1300; border-radius: 3px; }

/* Rodapé */
.rodape { max-width: 1240px; margin: 0 auto; padding: 8px 16px 32px; font-size: 13px; color: var(--ink-3); text-align: center; }
.rodape p { margin: 4px 0; }

.voltar { display: inline-flex; align-items: center; gap: 6px; font-size: 14px; font-weight: 600; text-decoration: none; margin-bottom: 10px; }
.prox-ant { display: grid; grid-template-columns: 1fr 1fr; gap: 12px; margin-top: 8px; }
.prox-ant a { padding: 14px 16px; text-decoration: none; color: var(--ink); }
.prox-ant a small { display: block; color: var(--ink-3); font-size: 12px; font-weight: 700; letter-spacing: .1em; text-transform: uppercase; }
.prox-ant a:last-child { text-align: right; }

/* ---------- Responsivo ---------- */
@media (max-width: 900px) {
  .grade { grid-template-columns: minmax(0, 1fr); }
  .indice { position: static; max-height: none; }
  .indice.recolhivel .indice-corpo { display: none; }
  .indice.recolhivel.aberto .indice-corpo { display: block; }
  .hero { grid-template-columns: 1fr; padding: 20px; }
  .topico-cab { top: 128px; }
  html { scroll-padding-top: 230px; }
}
@media (max-width: 640px) {
  .btn-busca span, .btn-busca kbd { display: none; }
  .btn-busca { padding: 9px; }
  .marca strong { font-size: 16px; }
  .marca small { font-size: 9.5px; }
  .topo-acoes .btn-topo#btn-instalar { padding: 7px 10px; font-size: 12.5px; }
  .ramos, .colunas-2, .prox-ant { grid-template-columns: 1fr; }
  .bloco, .callout { padding: 14px 16px; }
  .farmaco, .esq-grupo-cab, .esquemas > .esq-cab, .esq-intro, .esq-nota { padding-left: 16px; padding-right: 16px; }
  .topico-cab { position: static; }
  html { scroll-padding-top: 130px; }
  /* tabelas viram cartões empilhados */
  table.empilha thead { display: none; }
  table.empilha tr { display: block; border-top: 1px solid var(--line); }
  table.empilha td { display: block; border: 0; padding: 6px 12px; }
  table.empilha td:first-child { padding-top: 12px; }
  table.empilha td:last-child { padding-bottom: 12px; }
  table.empilha td[data-label]::before { content: attr(data-label); display: block; font-size: 10.5px; letter-spacing: .12em; text-transform: uppercase; color: var(--ink-3); font-weight: 700; }
  table.empilha tr.grupo td::before { content: none; }
  tbody tr:nth-child(even):not(.grupo) td { background: none; }
  table.empilha tr:nth-child(even):not(.grupo) { background: var(--surface-2); }
}
@media print {
  .topo, .rodape, .indice, .navsec, .prox-ant, .busca, .ferramenta { display: none !important; }
  body { background: #fff; }
  .card { box-shadow: none; }
}
@media (max-width: 900px) { .so-desktop { display: none !important; } }